Broad Area Colloquium For AI-Geometry-Graphics-Robotics-Vision
Two image processing problems in structural biology
Palo Alto Research Center
Monday, November 25, 2002, 4:15PM
I will talk about two different problems, both arising in efforts to
determine 3D structures of macromolecules.
The first problem is automatic analysis of images of protein solution
droplets, prepared by a high-throughput robotic system. The problem
is to classify the images into various categories: clear, precipitate,
crystal, and so forth.
The second problem is "particle picking" in cryo-electron microscopy.
Here the problem is to find the images of individual molecules or
molecular assemblies within a noisy, low-contrast micrograph. The
images are then combined using computed tomography to produce low- to
medium-resolution 3D structures.
About the Speaker
Marshall Bern has a M.A. in applied math and statistics from U. of
Texas, 1980, and a Ph.D. in computer science from UC-Berkeley,
1987. His research interests are computational geometry, combinatorial
optimization, graph algorithms, machine learning and bioinformatics.
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