According to the 1880 U.S. Census record for son Reuben, John McCullough was born in MD and Reuben's mother was born in PA.
http://freepages.genealogy.rootsweb.com/~millergonzalez/mccullough.html
This December, 2001 letter excerpt, sent to my grandmother by Ken Bowers, describes a connection between Reuben McCollough and John McCullough of southern Lancaster County.
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CENSUS YEAR: 1800 STATE: PA COUNTY: Lancaster TOWNSHIP: Dromore MICROFILM#: M32-39 ENUMERATOR: Jonathan Morre
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| |FREE WHITE MALES |FREE WHITE FEMALES |ALL | |
| | 10 16 26 | 10 16 26 |other | |
|HEAD OF HOUSEHOLD |to to to to 45 |to to to to 45 |free | |
PG# |LAST NAME FIRST NAME |10 16 26 45 up |10 16 26 45 up |Persons|Slaves|Remarks
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. . . . .
164 McCollough John . 1 1 . 1 . 1 2 . 1 1 .
. . . . .
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CENSUS YEAR: 1800 STATE: PA COUNTY: Lancaster MICROFILM#: M32-39 ENUMERATOR: Jonathan Morre
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| |FREE WHITE MALES |FREE WHITE FEMALES |ALL | |
| | 10 16 26 | 10 16 26 |other | |
|HEAD OF HOUSEHOLD |to to to to 45 |to to to to 45 |free | |
PG# |LAST NAME FIRST NAME |10 16 26 45 up |10 16 26 45 up |Persons|Slaves|Remarks
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. . . . .
227 McColough George . 2 . 1 . 1 . 1 1 . . .
. . . . .
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CENSUS YEAR: 1800 STATE: PA COUNTY: Lancaster MICROFILM#: M32-39 ENUMERATOR: Jonathan Morre
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| |FREE WHITE MALES |FREE WHITE FEMALES |ALL | |
| | 10 16 26 | 10 16 26 |other | |
|HEAD OF HOUSEHOLD |to to to to 45 |to to to to 45 |free | |
PG# |LAST NAME FIRST NAME |10 16 26 45 up |10 16 26 45 up |Persons|Slaves|Remarks
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. . . . .
241 McCullough Samuel . 1 . . 1 3 . . 1 . . .
. . . . .
Based on the page number, the township for Samuel and George's census records above would be Strasburg, Martick, Bart, or Ropho.
FIRST U.S. CENSUS OF PENNSYLVANIA 1790 U.S. Government Printing Office 1908 Drumore Township, Lancaster County Column 1 and 2 Head of Household Column 3 Free white males, 16 and upward including head of household Column 4 Free white males under 16 years of age Column 5 Free white females, including head of household Column 6 All other free persons Column 7 Slaves Column 1 2 3 4 5 6 7 -------------------- . . . . . McCulloch George 1 0 0 0 0 McCulloch John 4 3 4 0 0 McCulloch William 1 1 4 0 0 McCullough Alex 2 1 6 0 0 . . . . .